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Large Language Models

53 summarised stories about Large Language Models, each linking back to the original source. Browse all topics →

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Thursday, 6 August 2026

Large genome models used to design new viruses

Ars Technica 3 weeks ago 20 4 sources

Researchers at Stanford used large genome models to generate novel bacteriophage genomes that encode functional proteins and exhibit distinct features not easily evolved naturally. The models successfully created viral sequences by training on DNA data, demonstrating that genome-level AI design extends beyond protein engineering to full pathogenic organisms. This capability raises biosecurity concerns about potential misuse if similar models were developed to design viruses targeting larger organisms.

DeepAmbigQA: Ambiguous Multi-hop Questions for Benchmarking LLM Answer Completeness

Apple Machine Learning Research 3 weeks ago 11

Researchers introduced DeepAmbigQA, a dataset of 3,600 questions designed to test whether large language models can handle ambiguous entity names and multi-step reasoning in open-domain question answering. State-of-the-art models including GPT-4 achieved only 0.13 exact match on ambiguous questions and 0.21 on non-ambiguous ones, revealing significant gaps in answer completeness. The benchmark exposes the need for QA systems that better gather evidence across multiple entities and disambiguate between similarly named entities.

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