Team uses AlphaFold AI to redesign gene-editing proteins to make them safer
Ars Technica John Timmer
Researchers used AlphaFold to identify regions of gene-editing proteins that cause off-target DNA edits, then modified those regions to reduce errors. The modified proteins showed improvements in specificity compared to original versions. This approach could make gene-editing therapies safer by reducing the risk of unintended genetic changes in treated cells.
Why it matters
Google's AlphaFold can help ID what parts of a gene editing protein enable mistakes.
