Revealing a key protein behind heart disease

Google DeepMind · 10 months ago · 56

Scientists at the University of Missouri used AlphaFold and cryo-electron microscopy to map the structure of apoB100, the protein that forms the molecular scaffold of low-density lipoprotein (LDL) or "bad cholesterol." Researchers have sought this protein's structure for 50 years due to its size and complexity. The discovery could enable development of more targeted therapies for atherosclerotic cardiovascular disease, the world's leading cause of death.