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Scientific Research

126 summarised stories about Scientific Research, each linking back to the original source. Browse all topics →

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Friday, 11 September 2026

OpenAI says it made “substantial progress” on another Millennium Prize problem

The New York Times 1 month ago 25 ● 21 sources

OpenAI told The New York Times it has made substantial progress on a second Millennium Prize problem and is working out how to share the result. The report cites a second Millennium Prize problem, with the specific one not named. As a result, the details of which problem (rumored to be the Hodge Conjecture) and the findings’ public release remain pending.

SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign

Apple Machine Learning Research 1 month ago 17

SimpleDesign introduces an end-to-end protein design model that jointly generates amino-acid sequences and 3D structures instead of using a two-stage latent-space pipeline. SimpleDesign is trained on over 2M sequence–structure pairs. As a result, it uses a single-stage objective with sequence cross-entropy and structure regression while employing Transformer-based multimodal backbones, achieving competitive performance on co-design and unconditional generation benchmarks.

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