SimpleDesign: A Joint Model for Protein Sequence and Structure Codesign
Apple Machine Learning Research 1 month ago 17
SimpleDesign introduces an end-to-end protein design model that jointly generates amino-acid sequences and 3D structures instead of using a two-stage latent-space pipeline. SimpleDesign is trained on over 2M sequence–structure pairs. As a result, it uses a single-stage objective with sequence cross-entropy and structure regression while employing Transformer-based multimodal backbones, achieving competitive performance on co-design and unconditional generation benchmarks.
