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Open Source

277 summarised stories about Open Source, each linking back to the original source. Browse all topics →

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Monday, 21 September 2026

Improving synthesis prediction of small molecules at scale with RetroChimera

Microsoft 3 weeks ago 32

RetroChimera, a retrosynthesis prediction framework, was published in Nature and released as open-source to automatically propose synthesis routes for small molecules. In blind tests, PhD-level chemists preferred its individual reaction predictions over the preceding models and recorded literature reactions. The release enables researchers to use and improve an ensemble model that combines two approaches to rank routes better and scale synthesis planning beyond manual processes.

AI Security Is an Engineering Problem — How to Solve It at Every Layer of the Agent Stack

NVIDIA Blog 3 weeks ago 30 ● 12 sources

NVIDIA argues that AI security should be treated as engineering with enforceable controls, assigned owners, and evidence that protections work across the full agent stack. The article cites OpenShell as an open source secure runtime, and describes Cisco DefenseClaw and JFrog’s integration as partners building on it. As a result, organizations are pushed to build policy-enforcing boundaries into agent runtimes and to require repeated testing, traceable logs, and shared defensive evidence before deployment.

SCMD

Product Hunt 3 weeks ago 11

SCMD launches as an open-source, local review deck for the persistent memories saved by Claude Code. It is distributed with no cloud service and zero npm dependencies. Users can keep, delete, skip, undo, rewrite, and inspect staged memory decisions without telemetry, with deletes sent to restorable trash.

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