Automatic Ordinary Differential Equations Discovery For Biological Systems Using Large Language Model Powered Agentic System

arXiv cs.AI · 18 hours ago

Researchers developed MEDA, an AI system combining large language models and symbolic regression to automatically discover mathematical equations describing biological systems. The system successfully recovered correct state variables and achieved strong structural recovery across retrieval, extrapolation, and open-ended discovery tasks, with knowledge-guided constraints proving essential for producing biologically plausible models. This approach moves beyond data-fitting toward generating mechanistic models that can incorporate domain knowledge and automate parts of the scientific discovery process for biological systems.